FEN1 Inhibitor C2

Research use only, not for human use.

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

FEN1-IN-4

Others

Other Targets

hFEN1

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1995893-58-7

232.24

C12H12N2O3

>98% (HPLC)

DMSO:100 mg/mL (430.59 mM; Need ultrasonic)

On1c(=O)n(CC2CC2)c2ccccc2c1=O

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(-20℃)

With Ice Pack

≥ 2 years