FEN1 Inhibitor C2

Research use only, not for human use.

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.

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FEN1-IN-4

Others

Other Targets

hFEN1

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1995893-58-7

232.24

C12H12N2O3

>98% (HPLC)

DMSO:100 mg/mL (430.59 mM; Need ultrasonic)

On1c(=O)n(CC2CC2)c2ccccc2c1=O

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(-20℃)

With Ice Pack

≥ 2 years